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Turkish Journal of Cancer
2002, Volume 32, Number 1, Page(s) 12-19
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Investigation on antiproliferative effects of interferon-, 5-fluorouracil and hydroxyurea on human Burkitt lymphoma and erythroblastic leukemia cell lines
NİLÜFER GÜLMEN İMİR1, OSMAN NİDAİ ÖZEŞ2
1Department of Biology, Akdeniz University, Faculty of Art and Science, Antalya-Turkey, 2Indiana University Medical School, Cancer Research Center, Indianapolis, Indiana-USA

In this study, we investigated the growth inhibitory effects of IFN-, 5-FU, HU and their combinations on Daudi (Human Burkitt lymphoma) and K562 (Human erythroblastic leukemia) cell lines. Sensitivity of two leukemia cell lines to IFN- has shown large disparities. While Daudi cells were very sensitive to the antiproliferative effects of IFN-, K562 cells were more resistant. After showing different degree of sensitivities of Daudi and K562 cells to IFN-, we tested whether both cells showed similar responses against anticancer drugs such as 5-FU and HU. According to our results, Daudi cells were more resistant to the antiproliferative effects of 5-FU compared to K562. However, the initial antiproliferative effect of HU on K562 was less than that of Daudi cells. After showing the individual antiproliferative effects of IFN-, 5-FU and HU, we investigated whether these cells can be over sensitized to combination treatment of 5-FU and HU along with IFN-. To our results, on Daudi and K562 cells treated with IFN- and 5-FU, the antiproliferative effect of IFN- was diminished compared to the treatment with use of IFN-á alone in Daudi but not K562 cells. Treatment of the same cells with IFN- and HU resulted in synergistic antiproliferative effect on K562 cells compared to the individual use of either drug. However, co-treatment of Daudi cells with IFN-á and HU diminished the antiproliferative effect of IFN- compared to IFN-á use alone. Results presented here add new findings about the antiproliferative effects of IFN- and its combinations with 5-FU and HU on human Burkitt lymphoma and human erythroblastic leukemia cells to medicine and science world.

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