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Turkish Journal of Cancer
1994, Volume 24, Number 1, Page(s) 28-37
[ Summary ]
Clinicopathological study of anaplastic large cell (Ki-1 Positive) lymphoma
SEYRAN YİĞİT1, KAARLE FRANSSILA2
1Department of Pathology, Atatürk State Hospital, İzmir-Turkey
2Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Helsinki-Finland

A clinicopathological and immunohistochemical study of anaplastic large cell lymphoma (ALCL) (Ki-1 positive) was performed. There were 22 patients in whom the disease had a bimodal age distribution. The median age was 50.5 years, 9 patients were under 40 years and the male to female ratio was 2. Sixty three percent (63%) of patients presented with stage I or II disease. In January 1991, 15 patients (72%) were still alive, while 6 (28%) had died. In 12 of these 15 patients, follow-up studies covered at least one year, but in the remaining 3 patients, the follow-up time was less than one year. Except for one, all the deceased patients had stage III or IV disease. Cytomorphologically two distinct groups of ALCL can be separeted as group A and group B. In group B, 47% of patients died but in group A, 90% of patients were alive. Almost all patients received aggressive chemotherapy and radiotherapy. lmmunohistochemical studies were performed in 95% of cases and T cell lineage was found in 24%, B cell lineage in 19% and null cell lineage in 57%. ALCL represents a morphologically and immunologically heterogeneous group of lymphoid neoplasms with marked stage dependent prognosis.

[ Summary ]
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