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Turkish Journal of Cancer
1993, Volume 23, Number 4, Page(s) 206-210
[ Summary ]
L-Asparaginase induced hyperglycemia in two children with non-Hodgkin’s lymphoma
CANAN AKYÜZ1, İNCİ İLHAN2, MÜNEVVER BÜYÜKPAMUKÇU1
Departments of 1Pediatric Oncology, Hacettepe University Institute of Oncology
2Dr. Sami Ulus Children Hospital, Ankara-Turkey

Although hyperglycemia is a well-known complication of L-asparaginase administration in adult patients, there are very few reports about this side effect in the pediatric age group. We observed asparaginase induced non-ketotic hyperglycemia with normal insulin levels in two patients who were diagnosed as non-Hodgkin’s lymphoma. This combination of the metabolic effects of L-asparaginase may be explained by either a relation to a reduced peripheral action of insulin or an impaired peripheral glucose metabolism during the leukemic process.

[ Summary ]
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