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Turkish Journal of Cancer
1995, Volume 25, Number 1, Page(s) 23-33
[ Summary ]
Analysis of 123 patients with non-Hodgkin’s lymphoma: experience of Ege University Medical School
ALİ KESKİN1, MURAT TOMBULOĞLU2, SEÇKİN ÇAĞIRGAN2, FİLİZ BÜYÜKKEÇECİ2, MEVLÜT TÜRE3
Departments of 1Internal Medicine and 3Bioistatistics, Pamukkale University Medical School, Denizli
Department of 2Hematology Ege University Medical School, İzmir-Turkey

Prognostic factors were analysed in a series of 123 patients with non-Hodgkin’s lymphoma classified according to the working formulation. Twenty three cases (19%) were classified as low, 74 (60%) as intermediate and 26 (21%) as high grade lymphoma. Chemotherapy combinations used in these patients were COP (8/23 low grade patients), CHOP (90 patients with low, intermediate and high grade lymphoma), MACOP-B (10 patients with intermediate and high grade lymphoma) and ALL type regimens (8 patients with lymphoblastic lymphoma). Complete remission was observed in 63% of the patients and an analysis showed that failure to attain complete remission was associated with advanced stage disease, presence of constitutional symptoms, high serum LDH levels and low and high grade lymphoma. The 5 year probability of survival was 42% for the entire group of patients. Complete remission was the most important predictor of overall survival, limited stage disease, absence of B symptoms, intermediate grade lymphoma and low serum LDH levels were also associated with prolonged survival in univariate analysis. Thirty five percent of patients achieving complete remission were disease free at 5 years. Advanced stage and bone marrow involvement predicted a poor disease free survival.

[ Summary ]
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