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Turkish Journal of Cancer
1997, Volume 27, Number 4, Page(s) 161-170
[ Summary ]
Non-Hodgkin’s lymphomas in the elderly
İBRAHİM BARIŞTA1, GÜLTEN TEKUZMAN1, DİNÇER FIRAT1, EŞMEN BALTALI1, EMİN KANSU1, AYŞE KARS1, YAVUZ ÖZIŞIK1, ŞEVKET RUACAN2, BEDRİ UZUNALİMOĞLU2, ERGUN KARAAĞAOĞLU3
Departments of 1Medical Oncology, 2Pathology and 3Biostatistics, Hacettepe University Faculty of Medicine, Ankara-Turkey

In this retrospective study, 51 elderly patients with non-Hodgkin’s lymphoma (NHL) followed-up in the Hacettepe University Department of Medical Oncology between years 1973 and 1990, were evaluated. Out of 51 patients, 34 (66.7%) were male and 17 (33.3%) were female. The ages ranged from 65 to 85, with a median of 68 years. Constitutional symptoms were present in 43.1% of the patients. According to Working Formulation low, intermediate, and high-grade lymphomas comprised 38%, 50%, and 12%, respectively. The most common extranodal presentations were the bone marrow and the gastrointestinal system. The chemotherapy regimens most commonly used were CVP (cyclophosphamide, vincristine, prednisone), CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and BCNOP (bleomycin, cyclophosphamide, mitoxantrone, vincristine, prednisone). The response rates and the survival figures attained with these regimens were not statistically different (p>0.05). Median survival for all patients was 146 months. According to the univariate analysis the age and responsiveness to chemotherapy were important prognostic factors affecting the DFS, while grade was the only important factor affecting OAS. However, we were not able to demonstrate any important factor influencing the DFS and OAS in the multivariate analysis.

[ Summary ]
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