[ Main Page | Editorial Board | About | Instructions ]
[ Table of Contents | Archive | Archive Search | Online Submission | Sponsor | E-mail ]

Turkish Journal of Cancer
2007, Volume 37, Number 2, Page(s) 045-053
[ Summary ] [ Full Text ] [ PDF ]
The autologous hematopoietic stem cell transplantation in adult patients with lymphoma: Turkish Bone Marrow Transplantation Registry results
FİKRET ARPACI1, SELMİN ATAERGİN1, GÜNHAN GÜRMAN2, SEÇKİN ÇAĞIRGAN3, MUTLU ARAT2, AHMET ÖZET1, MELTEM AYLI4, MUHİT ÖZCAN2, ALİ ÜNAL5, TEOMAN SOYSAL6, YENER KOÇ7, ABDULLAH BÜYÜKÇELİK2, AHMET ÖZTÜRK8, ERCÜMENT OVALI9, HAKAN GÖKER10, BERKSOY ŞAHİN11, SEVGİ KALAYOĞLU BEŞIŞIK12, MAHMUT BAYIK13, ZAHİT BOLAMAN14, SEVİL BAVBEK15
1Gülhane Military Medical Academy, Department of Medical Oncology, Ankara-Turkey
2Ankara University İbn-i Sina Hospital, Department of Hematology and Oncology, Ankara-Turkey
3Ege University Medical School, Department of Hematology, İzmir-Turkey
4Numune Education and Research Hospital, Department of Hematology, Ankara-Turkey
5Erciyes University Medical School, Department of Hematology and Medical Oncology, Kayseri-Turkey
6İstanbul University Cerrahpaşa Medical School, Department of Hematology, İstanbul-Turkey
7Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara-Turkey
8Gülhane Military Medical Academy Haydarpaşa Hospital, Department of Hematology and Medical Oncology, İstanbul-Turkey
9Karadeniz Technical University Faculty of Medicine, Department of Hematology, Trabzon-Turkey
10Hacettepe University Faculty of Medicine, Department of Hematology and BMT Unit, Ankara-Turkey
11Çukurova University Faculty of Medicine, Department of Medical Oncology, Adana-Turkey
12İstanbul University Faculty of Medicine, Department of Hematology, İstanbul-Turkey
13Marmara University Faculty of Medicine, Department of Hematology and Immunology, İstanbul-Turkey
14Adnan Menderes University Faculty of Medicine, Department of Hematology, Aydın-Turkey
15İstanbul University Institute of Oncology, Department of Medical Oncology, İstanbu-Turkey

Turkish Bone Marrow Transplantation Registry (TBMTR) was established in 1995. Since 1992, data of adult lymphoma patients from fifteen national transplantation centers were collected and analyzed by TBMTR. A total of 437 adult lymphoma patients (185 Hodgkin's and 252 non-Hodgkin's lymphoma) undergoing autologous hematopoietic stem cell transplantation (HSCT) were registered in TBMTR from 1992 to 2002. Peripheral blood as stem cell source was used in 94% of the transplantations. Non-TBI (total body irradiation) conditioning regimens were administered in 88% of the cases. The 100-day transplantation-related mortality (TRM) was 11% in relapsed and 11% in primary refractory Hodgkin's lymphoma patients whilst TRM was found to be 9% and 30% in non-Hodgkin's lymphoma patients in first remission and in primary refractory cases, respectively. Infection was the most common cause of TRM. 10-year and 5-year survival rates were 50% and 49% in relapsed cases and primary refractory cases with Hodgkin's lymphoma, respectively; while in non-Hodgkin's lymphoma patients 10-year survival rate was 65% in cases in first remission, 7-year survival rate was 50% in sensitive relapse, 2-year survival rate was 0% in resistant relapse and 3-year survival was 24% in primary refractory cases. In conclusion, TBMTR results are comparable to EBMT and IBMTR results. Therefore, autologous HSCT may provide long-term survival in patients with Hodgkin's lymphoma as well as in patients with non-Hodgkin lymphoma in first remission and in sensitive relapse. [Turk J Cancer 2007;37(2):45-53]

[ Summary ] [ Full Text ] [ PDF ]
Turkish Journal of Cancer web sitesi Novartis Onkoloji'nin karşılıksız eğitim katkılarıyla hazırlanmıştır.
[ Main Page | Editorial Board | About | Instructions ]
[ Table of Contents | Archive | Archive Search | Online Submission | E-mail ]